At the time the metro line 6 was built, it was called "2 sud" ("line 2 south"). In 1900, the Étoile – Trocadéro segment of the line served the World Expo, while construction works continued up to Place d’Italie, and the ambitious Seine River crossing at Passy station was built, and opened to the public on 5 November 1903.
On 24 April 1906, the line was extended up to Place d’Italie, where a new maintenance centre was built. In October 1907, the line was merged with metro line 5, which had opened in June 1906, absorbing as a result the former metro line 2 Sud. The new metro line 5, linking Étoile station to Gare du Nord station, was operated in that configuration until 1942. There also used to be a metro line 2 nord (north), known as metro line 2 today.

The line that was originally numbered 6 served a short segment from Place d’Italie to Nation stations, and was commissioned on 1 March 1909.
In 1931, to provide better services to that year’s Colonial Exhibition, metro line 6 was “extended”, by using metro line 5 tracks. Metro line 6 then ran along a semi-circular southern route from Nation station to Étoile station, its current path. Following the end of the exhibition, the City of Paris ordered the CMP (Compagnie du chemin de fer métropolitain de Paris, Paris metropolitan rail company) to resume its earlier operations, which the CMP did for 11 years.
It was only after the extension of metro line 5 to Pantin station on 6 October 1942, during the German Occupation, that the current configuration of metro lines 5 and 6 took shape. As such, metro line 5 linked Place d’Italie to Église de Pantin, while metro line 6 connected Étoile to Nation.